ADE (Adverse Drug Event) Monitor has been developed to assist the staff pharmacists at Barnes and Jewish Hospitals (teaching hospitals affiliated with the university) with monitoring patient clinical data for potential adverse drug events (ADEs). Today it is a very common program not only in the United States.

This expert system is currently under developement, although a prototype has been running since June 1995. It monitors patient clinical data including demographics, drug orders, lab results, and drug allergies, for evidence that a patient has suffered an adverse drug event. If the event is detected early enough, intervention can occur. Whether or not the event is detected in time to intervene, some types of ADEs must be reported to external agencies in order for the hospital to maintain its accreditation status. The criteria for determining the signs that signal a potential ADE is being developed by local physicians and pharmacokinetic experts. The final version of the system will include a software application through which these experts can specify and modify the expert system rules. The system will also automate the process of reporting certain types of ADEs to U. S. government agencies such as the Food and Drug Administration (FDA).


The ADE Monitor is a hospital-based system (currently under development)


ADE Monitor is being developed by the Washington University School of Medicine Department of Internal Medicine Division of Medical Informatics.


Tim Bailey

Washington University School of Medicine, Department of Internal Medicine, Division of Medical Informatics, 660 South Euclid Campus, Box 8005, St. Louis, Missouri, 63110 USA, Phone: (314) 454-8651 or their homepage or

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